Getting the drug right — pharmacology, models and pumps — then titrating to the brain.
Plasma vs effect-site, ke₀, the falling TCI rate, a McFarlan stepped regimen, and three models on the same child. The workbench for the TCI and iTIVA labs.
Open →Seven sedation and five anaesthesia scenarios on the workbench — write your prediction, run it, then reveal what you should have seen. Progress stays on your device.
Start →The adult cockpit: Marsh, Schnider and Eleveld with plasma and effect-site targeting, tissue map and BIS — the reference point the paediatric models depart from.
Open →How injection speed shapes the plasma peak while the effect-site peak barely moves — speed buys plasma risk, not hypnotic depth.
Open →Why 'half-life' misleads, and why the longer you infuse the slower the fall.
Open →Blood, muscle and fat as tanks — the picture behind every number on a TCI pump.
Open →A guided pathway from first principles to running a full intravenous anaesthetic — the place to consolidate what you practised today.
Start →